Atherosclerosis Pathogenesis And Microvascular Dysfunction

Atherosclerosis Pathogenesis and Microvascular Dysfunction PDF
Author: Axel Haverich
Publisher: Springer
Category : Medical
Languages : en
Pages : 130
View: 4062

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Book Description:
This book provides new perspectives on the pathogenesis of atherosclerosis. Chapters cover atherosclerosis risk factors, the effect of growth and aging on vascular architecture, and the crucial role the microvasculature plays in atherosclerosis development. Microvascular dysfunction would explain why the well-known risk factors actually put individuals at higher risk. This pathomechanism would also hold true not only for obstructive atheroma formation but also for aneurysmal dilatation as well as for aortic and peripheral artery dissection. When seen through this lens, novel preventive and therapeutic opportunities can be envisioned. Atherosclerosis Pathogenesis and Microvascular Dysfunction proposes a single unifying mechanism of atherosclerosis development and describes potential preventative and therapeutic avenues based on this concept. It therefore represents a timely and valuable resource for internal medicine, cardiology, angiology cardiovascular surgeons, pathology clinicians, researchers, trainees, and students.


Pathogenesis Of Atherosclerosis

Pathogenesis of Atherosclerosis PDF
Author: A. Wayne Orr
Publisher: Biota Publishing
Category : Medical
Languages : en
Pages : 125
View: 7086

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Book Description:
The circulatory system provides the tissues of the body with oxygen and nutrients for survival, allows for the dissemination of inflammatory cells, and clears metabolic waste from building up and damaging tissue. Atherosclerotic disease, the build-up of fat, inflammatory cells, and fibrotic tissue in the vessel wall, hinders this function, resulting in inadequate perfusion of the target tissue. Hypoxia, or lack of oxygen, rapidly results in cellular dysfunction that profoundly affects the functionality of the overall tissue. Atherosclerosis-associated tissue ischemia and hypoxia because of loss of blood flow underlies several significant disease pathologies including ischemic heart disease, stroke, and peripheral artery disease. In this eBook, we examine the process of atherosclerotic plaque formation both at the cellular level and the level of clinical presentation. Through this book, we hope to impart to the reader a better understanding of how vessel structure, environmental risk factors, and genetic predisposition contribute to atherosclerotic disease and how current and future therapies seek to circumvent the cellular processes contributing to plaque formation to reduce atherosclerotic plaque burden and clinical complications. Table of Contents: List of Videos / Introduction to Atherosclerosis / Epidemiology / Endothelial Cell Activation and Arterial Hemodynamics / Cholesterol and Cardiovascular Disease / Inflammation in Atherosclerosis / Smooth Muscle Cells and Plaque Vulnerability / Diagnosing Atherosclerotic Disease / Treatment and Prevention / Summary and Future Perspectives / References / Author Biographies


Atherosclerosis Risk Factors

Atherosclerosis Risk Factors PDF
Author: James J. Maciejko
Publisher: Amer. Assoc. for Clinical Chemistry
Category : Medical
Languages : en
Pages : 192
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Lipoproteins And The Pathogenesis Of Atherosclerosis

Lipoproteins and the Pathogenesis of Atherosclerosis PDF
Author: James Shepherd
Publisher:
Category : Medical
Languages : en
Pages : 191
View: 2662

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Book Description:
Lipoprotein disorders are among the most common metabolic derangements encountered in industrialised countries. Figures for the United States of America, for example, reveal that more than half of the adult population have too high plasma cholesterol levels. It is not surprising that ischaemic heart disease remains the commonest cause of death in the western world. This volume focuses on the origin of the problem by exploring the factors which govern the structure and metabolism of human plasma lipoproteins and those which regulate lipoprotein interaction with the developing atherosclerotic lesion. Secondly, recent advances in the pharmaceutical industry have led to the development of powerful and effective new lipid lowering drugs. The practising physician needs to know when to use these agents and what to expect of them. This topic is examined in some detail to provide a basis for rational lipid lowering pharmacotherapy if dietary intervention fails. The implementation of effective intervention programs offers the prospect of reducing the impact of heart disease and improving the quality and expectation of life in the community.


Atherosclerosis And Oxidant Stress A New Perspective

Atherosclerosis and Oxidant Stress  A New Perspective PDF
Author: Jordan L Holtzman
Publisher: Springer Science & Business Media
Category : Medical
Languages : en
Pages : 247
View: 350

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Book Description:
Vascular injury is initiated by oxidant injury to the vessel wall. This volume is organized around the role of oxidant damage in this disease process and provides a collection of the most recent studies, representing various disciplines that can serve as the basis for further improvements in our understanding and control of cardiovascular and cerebral vascular disease.